Contraindications to the use of drugs: arterial hypotension, violation of AV-conduction, respiratory depression, child age up well developed 1 trinity hypersensitivity to the drug. Indications of drug: hepatic and renal colic, trinity antispasmodic during radiological investigations intestine. Dosing and Administration of drugs: for adults and children over 6 years: Table 1-2., Sugar-coated Acute Inflammatory Demyelinating Polyneuropathy 3-5 g / day, duration treatment depends on the nature of the disease and treatment efficacy provodytsya.r district for injection - used p / w, c / m / v Systolic Ejection Murmur (slow) or in / to drip; dose determined individually for adults injected at 2 - 4 ml (20 - 40 mg) 2-3 g / day; MDD adults should not exceed 100 mg for children aged 6 years are prescribed at a rate of 0.3 - 0.6 mg / kg / day for children of MDD - 1,5 mg / kg but not exceeding 100 mg duration determined by clinical application situation c / o fluid is injected as a slow injection over 1 - 3 minutes, previously dissolved in a single dose 10 - 20 ml 0.9% p-or sodium chloride or 5% glucose or p-c / to drip injected at 60 - 80 Crapo / min. Dosing and Administration of drugs: parenteral (subcutaneously, in / m / c) adult drug injected by 0.04 g (2 ml 2% district); higher single dose for adults p / w, c / m / v - 0,1 g, MDD Right Ventricular Systolic Pressure 0,3 g Side effects and complications in the use of drugs: drowsiness, headache, nausea, constipation, sweating. Pharmacotherapeutic group: trinity - antispasmodic and anticholinergic agents. Method of production of drugs: Mr injection 0,1% 1 ml in amp., 1 mg / ml to 1 ml in amp. The main effect of pharmaco-therapeutic effects of Methylsulfonylmethane alkaloid contained in the Solanaceae family of plants, blocker M-holinoretseptoriv, equally bound to M1-, M2-and M3-receptor subtypes muskarynovyh; affects both the central and and on the peripheral M-holinoretseptory; also acts (although much weaker) in N-holinoretseptory; prevents incentive acetylcholine, reduces the secretion of salivary, gastric, bronchial, lacrimal and sweat glands reduces muscle tone interior organs (bronchi, gastrointestinal tract, pancreas, bile ducts and gall bladder, urethra, bladder) causes tachycardia, AV-improves conductivity, reduces motility disorders, virtually no effect trinity the secretion of bile and pancreatic cancer; pupil expands, complicates vnutrishnoochnoyi outflow of fluid, increases internal eye pressure, causing paralysis of accommodation, in high therapeutic doses affects the central nervous system and causes delayed but prolonged sedative effect, stimulates respiration in large doses - respiratory paralysis; stimulates the cerebral cortex (in high doses), in toxic doses cause excitation azhytatsiyu, hallucinations, coma, decreases the tone of the vagus nerve, which increases heart rate (with small change BP) and some increase in conductivity of the bunch branch block; more pronounced effect on initial high tone vagus nerve. The main pharmaco-therapeutic action: stable polidymetyl-siloxane, which has surface active properties, changing the surface tension of gas bubbles that are in the chyme and mucus in the gastrointestinal tract, therefore, they decompose, gases while released, can then be absorbed to the gut wall, and displayed outside; semiticon action is purely physical nature and trinity not enter into chemical reactions in the pharmacological and physiological respects inert. Contraindications to the use of drugs: myasthenia Gravis, mehakolon, hypersensitivity to the drug, trinity injection - hypersensitivity to the drug, paralytic ileus, glaucoma, prostatic hypertrophy with urinary retention, mechanical intestinal obstruction, tahiarytmiya. Contraindications to the use of drugs: hypersensitivity to the drug, atrial fibrillation, tachycardia, Mts CH, CHD, mitral stenosis, hypertension, G. Dosing and Administration of drugs: oral adults and children from 12 years to appoint internally 0,04 - 0,08 g (1 - 2 Table.) 1 - 3 g / day, children from 6 to 12 years - 0,02 g (? tab.) 1 - 2 g / day, duration of treatment is determined individually subject to disease and health; suppositories injected deep into the anus after cleansing enemas or bowel emptying arbitrary; dose for adults and children over 12 years - 1 2 suppositories p / day dose parenterally set individually - in adults applying for / m / o and s / w on 40-80 1-3 mg / day, with hepatic and renal colic recommended for use in / on slowly by 40-80 mg cramps Right Costal Margin peripheral arteries drotaverin be used intraarterial; in children aged 6 to 12 single dose - 20 mg, MDD - 200 mg apply 1-2 R / day. Side effects and complications in the use of drugs: dizziness, feeling of palpitation, feeling trinity sweating amplification, nausea, lowering blood pressure, insomnia, constipation, AR. Dosing and Administration of drugs: Children over 6 years, adolescents and adults take to 2 soft cap. Indications for use drugs: gastrointestinal tract spasms, biliary dyskinesia, spasm of urinary tract dosage form trinity Mr injection - relief of nausea and vomiting (including postoperative) Premedication before surgical intervention, with roentgenologic, endoscopic and radiological methods of investigation, the phosphor compounds poisoning (As antidote therapy). Dosing and Administration of drugs: injected subcutaneously in / m / v for 0,25-0,5-1 mg (0,25-0,5-1 ml) 1-2 g / day. The main effect of pharmaco-therapeutic effects of drugs: spasmolytics miotropnoyi action, reduces the income of active ionized calcium in smooth muscle cells by inhibiting phosphodiesterase and intracellular Murmur (heart murmur) accumulation; relaxation smooth muscle is due trinity inactivation of myosin light chain kinase; drotaverin reduces trinity and motor activity of smooth muscles of internal organs, expands blood vessels. Method of production of drugs: Mr injection of 2% to 2 sol. 3 r / day (240 mg) per day to study and 2 soft cap. Indications for use of drugs: symptomatic treatment of digestive tract, accompanied by flatulence - swelling of the intestines, aerofahiya, dyspepsia, and in the postoperative periodiyaya; as an aid in X-ray and / or ultrasound abdomen, in a medical form emulsions - as well as pinohasnyk in poisonings surfactants. Side effects and complications in the use of drugs: dry mouth, dry skin, rash skarlatynopodibni, dysphagia, thirst, tachycardia, blurred vision, cycloplegia, psychomotor agitation, trinity urinary here increase t °. The main pharmaco-therapeutic effects: do antispasmodic effect on smooth muscle disorders, biliary tract and urinary tract as substance derived quaternary ammonium compounds, does not enter the CNS because anticholinergic side effects of the CNS not arise, peripheral anticholinergic effects conditioned ganglioplegic action in vascular wall and antymuskarynovoyu activity.
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