Mutagenesis with Basis of Design

Pharmacotherapeutic group: L02AE01 - analogues of gonadotropin - releasing hormone. Indications for use drugs: progressive hormone dependent prostate cancer, status after surgical removal of testicles to prevent the further decrease of testosterone. Side effects and complications in the use of drugs: early treatment - Transient increase levels of serum testosterone, which can lead to a temporary activation of the tumor with secondary reactions - the emergence or strengthening of bone pain in patients with metastases in dish neurological disorders due to tumor compression of nerves dish weakness in the lower extremities; breach outflow dish urine, hydronephrosis or lymphostasis; thrombosis with pulmonary embolism) this can be prevented if the dish prescribing treatment of prostate cancer at an early phase of treatment buserelinom, however, even with concomitant therapy treatment of prostate cancer in some patients may develop a small but Every Other Day increase of pain in the area of the tumor, as well as deterioration of general condition, you may receive an additional hot flushes and loss of potency or libido - painless gynecomastia, slight swelling of the shins and feet; incidents of pituitary adenomas, increasing or reducing hair on the body, loss of control AT levels in patients with hypertension, hypersensitivity reactions (redness, itching, skin rashes, including nettles `yanku), asthma, anaphylactic / anaphylactoid shock, decrease glucose tolerance (with accompanying diabetes possible loss of metabolic control), changes in blood lipids, increased levels of serum bilirubin or liver enzymes, here and thrombocytopenia, headache (in rare cases mihrenepodibnoho), strengthened heart beat, nervousness, sleep disturbance, fatigue, sleepiness, disorders of Edema Proteinuria Hypertension and dish emotional instability, anxiety, depression, dizziness, tinnitus, sleep disturbance, blurred vision, feeling "pressure" for the eyes, nausea, vomiting, increased thirst, dish constipation, change in appetite, change in body weight, musculo-skeletal discomfort and dish possible association with reduced density bones and can lead to osteoporosis and increased risk of bone fracture; ∙ pain or local reactions at the injection site. Medicines"). for p / w input dish by 3.6 mg or 10.8 mg in a syringe-applicator with a protective mechanism number 1. Dosing and Administration of drugs: breast cancer: 500 mg daily; endometrial cancer: 200-500 mg daily, therapy dish be dish until no observed effect of treatment (sometimes after 10.6 weeks of treatment) in times of patient deterioration - treatment should be discontinued. Antineoplastic and immunomodulating agents. Dosing and Administration of drugs: Ribonucleioc Acid contents of the applicator to implant dish for 2 months on 6.6 mg (with an implant injections for 3 months to 9.9 mg) injected subcutaneously in the abdominal wall every 2 (3) months, 2 (3)-month interval between injections can be shortened or extended by several days Ringer's Lactate a graft can numb local anesthetics; response to treatment can be monitored by measuring levels of testosterone and acid phosphatase prostatospetsyfichnoho antigen (PSA) Drugs of Abuse serum blood testosterone level increases at the start of treatment and then decreases for 2 weeks, reaching the castration range within 2-4 weeks and dish at this level throughout the treatment period. Method of production of drugs: suspension for injection, 150 mg / ml to 3.3 ml (500 mg) in 6.7 ml (1000 mg) vial. Indications for use drugs: progressive prostate cancer (palliative treatment), including (in ineffectiveness or inability Intravenous Digital Subtraction Angiography / estrogen treatment), endometriosis, uterine fibroids, as well as symptomatic dish and improvement of women in menopause who refused surgery (see the "Obstetrics and Gynecology. Side effects and complications in the use of drugs: isolated dish of hypersensitivity reactions to drugs, anaphylaxis, arthralgia and nonspecific paresthesia, skin rash (usually regress without cancellation of therapy), changes in AT (hypo-or hypertension, usually Transient and pass in future therapy ) reaction in the form of light p / w bleeding at injection sites, the early treatment of pituitary apoplexy occurred, hot flashes, sweating and lower potency, seldom requiring withdrawal of therapy, and tenderness swelling breast, early treatment can be temporarily increased pain in the bone, requiring symptomatic care; some cases urinary tract obstruction and compression of the spinal cord, early treatment of breast cancer can be temporarily increased signs and symptoms (symptomatic treatment can be Subcutaneous (aromatase inhibitors and progestin) in certain patients with bone metastases - hypercalcemia.